Profhilo vs. Profhilo Structura: Understanding the Differences 

Profhilo and Profhilo Structura are both hyaluronic acid bio-remodelling injectables, but they’re designed for different jobs. Profhilo is a lighter, more fluid formula that spreads through the skin to boost hydration, elasticity, and overall glow — it’s the go-to choice for improving skin quality and mild laxity. Profhilo Structura, on the other hand, is a firmer, more structured formula built specifically to target deeper concerns like jawline definition and lower face sagging, where more lifting and support is needed.

So which one is right for you? If your main concern is dull, dehydrated, or crepey skin across the face and neck, Profhilo is likely the better starting point. If you’re noticing loss of definition along the jawline or early jowling, Profhilo Structura is designed to address that more directly. Many patients also combine both treatments as part of a tailored plan. The best way to know for sure is a personalised assessment — book a free consultation and one of our practitioners will recommend the right option for your skin.

What is Profhilo?

Profhilo is known for its:

• Skin hydration — the high concentration of hyaluronic acid attracts moisture, making the skin plumper and more hydrated.
• Collagen stimulation — it encourages the production of collagen and elastin, improving skin’s firmness and elasticity.
• Natural results — since it doesn’t change facial volume, the results are more subtle, with improved skin quality over time.

Typically, Profhilo is used for facial areas that show signs of ageing, like the cheeks, under the eyes, neck, and hands. The treatment involves two sessions, spaced about four weeks apart, with noticeable improvements in skin texture, tightness, and overall radiance.

What is Profhilo Structura?

Profhilo Structura is an advanced version of the original Profhilo treatment. While it contains the same key ingredient — hyaluronic acid — Profhilo Structura is designed to offer more targeted skin remodelling and firming. The “Structura” version is aimed at patients who need more structural support, particularly in the lower face, where it helps restore definition and lift mild to moderate sagging.

Two sessions are generally required, spaced a month apart, and results can be seen four to six weeks after treatment.

Profhilo vs Profhilo Structura: Key Differences

Both treatments use hyaluronic acid to improve skin quality, but they’re built for different concerns. Here’s how they compare side by side:

	Profhilo	Profhilo Structura
Best for	Hydration, glow and general skin quality	Jawline definition, lower face sagging and firmness
Formulation	Lighter, more fluid hyaluronic acid	Firmer, more structured hyaluronic acid
Areas treated	Face, neck, hands, décolletage	Primarily the lower face — jawline and cheeks
Sessions needed	2, around 4 weeks apart	2, around 4 weeks apart
Results visible from	Around 4 weeks	4–6 weeks
Price	£225 per treatment	£250 per treatment

Many patients ask whether they can have both — you can. It’s common to combine Profhilo for overall hydration with Profhilo Structura for targeted jawline support, and your practitioner will confirm whether that’s the right plan for you at your consultation.

Results, Longevity and Before & After

Because both treatments work gradually by remodelling the skin from within, results build over the two-session course rather than appearing instantly. Most patients see visibly smoother, more hydrated skin from around four weeks after their first session, with the full effect settling in after the second. Results from a course typically last four to six months, depending on your skin and lifestyle, after which a top-up session is recommended to maintain them.

We don’t publish stock before-and-after photos on this page, because results vary from patient to patient and we’d rather you see genuine outcomes than generic marketing images. You’re welcome to ask to see real patient results during your free consultation, and you can read verified patient reviews on our Google Business Profile in the meantime.

Is It Safe? Suitability and Aftercare

Profhilo and Profhilo Structura are both well-established hyaluronic acid treatments with a strong safety record when carried out by a qualified practitioner. As with any injectable, mild redness, swelling or small bumps at the injection sites are common straight after treatment and typically settle within 24–48 hours.

These treatments may not be suitable if you’re pregnant or breastfeeding, have an active skin infection in the treatment area, have a known allergy to hyaluronic acid, or have a history of keloid scarring. A full medical history is always taken at your consultation so your practitioner can confirm the right treatment — or advise against it — before anything is booked.

Frequently Asked Questions

What is the main difference between Profhilo and Profhilo Structura?

Profhilo is a lighter formula focused on hydration and overall skin quality, used across the face, neck, hands and décolletage. Profhilo Structura is a firmer formula designed to add structure and lift, mainly used on the jawline and lower face. Many patients use one, the other, or both together.

How much does Profhilo Structura cost?

Profhilo Structura costs £250 per treatment at The Hamble Clinic, and a course of two sessions is usually recommended. Profhilo costs £225 per treatment on the same two-session basis.

Is Profhilo Structura safe?

Yes, when carried out by a qualified practitioner following a full consultation. It’s a well-established hyaluronic acid treatment, though it isn’t suitable for everyone — your practitioner will check your medical history and skin before recommending it.

Can I have Profhilo and Profhilo Structura together?

Yes. It’s common to combine Profhilo for general hydration and glow with Profhilo Structura for targeted jawline and lower face support, as part of one tailored treatment plan.

Is Profhilo Structura worth it?

For patients whose main concern is loss of jawline definition or early sagging, Profhilo Structura is designed specifically for that, which makes it more targeted than standard Profhilo. Whether it’s the right choice for you depends on your skin and goals, which is best assessed at a free consultation rather than guessed from photos online.

Both Profhilo and Profhilo Structura offer real benefits for skin rejuvenation, but the key difference lies in the depth and focus of their treatments. Profhilo is excellent for hydration and improving skin quality, while Profhilo Structura goes a step further by targeting skin sagging and offering more structural support. Whatever your skin concerns, a personalised assessment with a qualified aesthetic practitioner is the best way to find the right treatment for you.